The prevalence of H. pylori in Myanmar is still high despite an overall decline in Asia.More than 50% of Gastric cancer were associated with H pylori infection and characterized in intermediate risk for gastric cancer because of predominant Western type with diverse charactertic of Cag A virulent strain and babA-positive strain. Inaddition to that other factors like host genetics and environmental factors may play a role in gastric carcinogenesis in Myanmar.