Disorders of Gut Brain Interaction (DGBI), such as irritable bowel syndrome, functional dyspepsia, and functional heartburn comprise a significant portion of patients seen in outpatient gastroenterology practices. The pathophysiology of DGBIs involves cognitive-affective factors that contribute to brain-gut dysregulation and can play a key role in exacerbating symptoms. Psychological treatments, now referred to as brain-gut psychotherapies, are highly successful at improving gastrointestinal symptoms and quality of life for patients with these conditions. This presentation will provide an overview of the rationale behind using psychological interventions to treatment DGBIs, the efficacy of the most common brain-gut psychotherapies, and guidance on how to identify patients most likely to benefit.