Special Considerations in NAFLD Patients With Concomitant Chronic Hepatitis B Infection 21 Aug 2021 16:42 16:52

Special Considerations in NAFLD Patients With Concomitant Chronic Hepatitis B Infection 21 Aug 2021 16:42 16:52

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Patients with NAFLD and concomitant chronic hepatitis B are increasingly prevalent. Individually, both NAFLD and Chronic hepatitis B can impact on liver function and potentiate progressive disease and complications such as cirrhosis or hepatocellular carcinoma. In concurrent CHB-NAFLD, with the complex interplay between the two diseased entities, clinical characteristics may differ from patients with single disease. While hepatic steatosis is associated with diminished hepatitis B viral seromarker variables, paradoxically, concurrent disease appears to have a poorer overall outcome. Clinicians may encounter challenges in identifying predominant drivers of liver injury and choosing appropriate treatment.  Treatment of chronic hepatitis B should proceed as indicated, but it is equally important to be vigilant about the other metabolic factors intertwined with the NAFLD component.  As such, a multi-disciplinary holistic approach should be applied to patients with NAFLD and concomitant chronic hepatitis B. This presentation provides a review of current evidence and practical considerations in managing this disease.

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